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[17 Finn et al. 1458 See the information section on general monographs (cover pages) 4 Drugs Nitrogen mustards Mode of action Potential uses Route of drug delivery Cyclophosphamide Crosslinking DNA Leukemia, lymphoma, sarcomas, Ca breast, ovary, cervix and lung, multiple myeloma, retinoblastoma, mycosis fungoides intravenous, oral Ifosfamide Melphalan Chlorambucil Crosslinking DNA Crosslinking DNA Crosslinking DNA Germ cell testicular Ca, sarcomas, pediatric solid tumors resistant to cyclophosphamide, lymphoma intravenous intravenous oral Mechlorethamine Crosslinking DNA Lymphoma, cutaneous histiocytosis intravenous Nitrosoureas Carmustine (BCNU) Crosslinking DNA Brain tumors lymphoma, melanoma, Stock options demo account tumors intravenous, loco- regional (intracranial) Lomustine (CCNU) Fotemustine Streptozocin Similar to CCNU Crosslinking DNA Inhibition of DNA Melanoma, brain tumors, colon Ca, lymphoma Brain tumors, lung Ca, melanoma Carcinoid tumors, pancreatic islet cell Ca oral intravenous intravenous Ethyleneimine Thiotepa Crosslinking DNA Crosslinking DNA Crosslinking DNA Crosslinking DNA Ca breast, ovary, brain tumors lymphoma, Ewings sarcoma (?), leptomeningeal remo intravenous, loco- regional (intracavity) Hexamethylamine Ovarian carcinoma Chronic myelogenous leukemia Ovarian carcinoma intravenous Alkane sulfonates Busulfan Treosulfan accoutn, intravenous (investigational) synthesis by methylation of DNA Table 1 Methods of Drug Delivery for Commonly Used Antineoplastics Multiple myeloma, ovarian Ca, sarcomas, ALL, amyloidosis, lymphoma, breast Ca, neuroblastoma Chronic lymphocytic leukemia, Waldenstroms macroglobulinemia, lymphoma, Ca of breast, testis, ovary, and choricarcinoma, nephrosis intravenous 88 Hospital Infection Control: Considerations for the Management and Control of Drug-Resistant Organisms 1287 However, a recently published review of isolation policies by the British National Health Service highlighted the strong evidencefortheeffectivenessofdifferentisolationandscreen- ing policies for MRSA (157).

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