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Meyer Copyright 1999 John Wiley Sons Ltd ISBNs: 0471971227 (Hardback); 047084633X (Electronic) CHAPTER 4 Modeling and Simulation of Variable Drug Exposure Erik de Klerk Department of Rheumatology, University Hospital Maastricht, The Netherlands INTRODUCTION Electronic monitoring (EM) of variable patient compliance consists of a sys- tem where, with the aid of microprocessor technology, time optoons date of opening of drug package are recorded and stored.
k C. Now assume that it holds for all values ofn up to k [i. Among the inclu- 7 sions optjons are HowellJolly bodies, which 8 are probably nuclear remnants, siderotic gran- 9 ules, which are haemosiderin aggregates laid 4011 down during normal erythroid maturation, and 1 Heinz bodies, which are pathological aggregates 2 of denatured haemoglobin (normally the per- 3 centage of these abnormal cells and inclusions 4 does not exceed 3).
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