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Effects of desipramine and fluvoxamine treatment on the prolactin response to tryptophan. Applications of NMR Techniques Given the previous introduction to the basic physics used in the various schemes for filtering NMR spectra from drugreceptor interactions, we now turn to an examination of applications of these techniques in specific examples applied to different classes of drug discovery.

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Cattaneo, as antihistaminic agents 437 Piperine, as active ingredient of Chinese folk medicine 322 Plant growth regulators, structural requirements 247 Plasmin, amino acid sequence of 90 inhibitors of 88, 89 Potassium channel activators, cromakalim analogs nicorandil and analogs pinacidil and analogs Prazosin 373 Protein, 237, 238, 256 250 250, 257 homologous proteins, structural similarity modelling of three-dimensional structures prediction of three-dimensional structure of three-dimensional structure of 50 Protein data bank (Brookhaven) 7, 60, 216 Protein engineering 51 Protein sequence database (NBRF) 216, 234 Pyrazines, substituted, 50 51, 56, 58 50 structure-hydrophobicity relationships Pyridazines, substituted, 160, 173, 178, 179, 181 structure-hydrophobicity relationships 163 Pyridines, substituted, structure-hydrophobicity relationship 155 Pyrimidines, substituted, structure-hydrophobicity relationships Pyrimidinyl(thio)salicylates 244, 263 QSAR, 161-162 for acute toxicity of acrylamides 466 for adsorbability of testosterones 128 for anticonvulsive activity of cinnamides for anticonvulsive effect of phthalides 300 for antihistaminic activity of 2-piperazinylbenzimidazoles for antiulcerative effect of piperazine-acetamides and-acetates 430, 432, 433, 435 for antiulcerous effect of heteroaromatic aldehyde semicarbazones 311 of benzamide-type LT-antagonists 347, 356 for binding affinity for androgen receptor 138, 141 for binding affinity for estrogen receptor 134, 143 for binding affinity for glucocorticoid receptor 129 326, 328 438, 439, 442, 443 Application of Pathology in Safety Assessment 517 144.

Oral lyophilisates comply with the test; the limits are approved by the competent authority. Mortality (14 for rHuEPO and 15 for placebo) and adverse clinical event rates did not differ, however. 11) © 2000 by CRC Press LLC D D expÈ- EA ̆ 0 Í kT ̇ Î ̊ F D ¶N ¶x ¶N ¶F ¶t ¶x ¶N ¶ ÊD ¶Nˆ D ¶2N ¶t ¶xÁË ¶x ̃ ̄ ¶x2 N NerfcÊxˆ (x,t) 0 ÁË2 Dt ̃ ̄ Colombia Cities of the World 184 Antioquia.

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In Section 9:3, we will see that the speed of propagation of pressure information, the speed of sound, is roughly (Pρ)12, which is also roughly the speed of ideal gas particles (431). Biol.

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